Life in the limelight can be a lonely place for celebrities. Long work days and weekends packed with events and press tours make it hard enough to have some alone time, let alone time for hangouts with friends.

Still, these A-listers found everlasting friendship among a sea of people on the red carpet. Whether they met before getting their big break or connected while filming a hit TV show, fame not only gave them a paycheck, but a best friend for life…

1. Bette Midler and 50 Cent: This unlikely pair met through the New York Restoration Project. They instantly bonded over their passion to make New York a better place. Midler said, “He’s really made my life worth living.”

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2. Justin Timberlake and Jimmy Fallon: Their friendship goes back to the 2000s when Timberlake appeared on Saturday Night Live along Fallon. “I was totally nervous and [he was] nervous and we both ended up having a good night.”

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3. Leonardo DiCaprio and Tobey Maguire: Back in the ’80s, both actors often vied for the same roles. The 12-year-olds didn’t let it come between them, though. They’re still best friends to this day. They even had the opportunity to star together in The Great Gatsby.

4. Oprah Winfrey and Gayle King: Forty-three years of friendship began when Winfrey and King met while working at a TV station in Baltimore, Maryland. Oprah says that there’s “not a better human in the world,” in regards to her bestie, Gayle.

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5. Amy Poehler and Tina Fey: The Saturday Night Live legends have been friends for well over two decades after meeting at a Chicago improv theater in 1993. Since then, they’ve starred in a number of movies together, including Mean Girls and Sisters, and spent five years as co-stars on Saturday Night Live.

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6. Sophie Turner and Maisie Williams: Starring as on-screen sisters in HBO’s Game of Thrones, Turner and Williams got matching tattoos after they learned the show was ending. Turner said, “She’s my best friend. She’s my soul mate. I love that girl to pieces.”

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7. Cameron Diaz and Drew Barrymore: These two met at a Beverly Hills coffee shop. It wasn’t until Barrymore was producing the movie Charlie’s Angels in 2002 that she called Diaz and offered her a role — the rest is history.

8. Chris Hemsworth and Tom Hiddleston: The actors’ off-screen relationship is much different than what you see on screen. Hemsworth said, “You either have chemistry with someone or you don’t…” While Hiddleston followed, “It’s quite literally a bromance.”

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9.  Kim Kardashian and Jonathan Cheban: Not all Hollywood friendships begin on the red carpet. This decade-long bond blossomed when Cheban accidentally sat next to Kardashian at a birthday party. What a happy mistake.

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10. Julianne Hough and Nina Dobrev: After meeting through mutual friends in 2013, Hough and Dobrev became inseparable. Dobrev soaked up the sun at Hough’s fun-filled bachelorette weekend in the Caribbean and stood next to her when she said, “I do.”

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11. Robert Downey Jr. and Jude Law: This dynamic duo became friends after co-starring in the two Sherlock Holmes films in 2009 and 2011. It blossomed into a beautiful bromance on and off-screen. Downey Jr. and Law are gearing up to film a third franchise installment set to be released in 2020.

12. Jennifer Aniston and Courteney Cox: After meeting on the hit TV show Friends, Aniston and Cox have been besties for 25 years. The pair remained so close that Cox was Aniston’s maid of honor in her wedding to ex-husband Justin Theroux in 2015. “I’ll be there for you” wasn’t just their show’s theme song!

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13. Jay Z and Kanye West: Before West was a GRAMMY winner, Jay Z recognized his talent right off the bat. They’ve been closer than family for a long time. Although it’s been in the media that the rappers have had several rough patches, Jay Z still calls Kanye “his brother.”

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14. Taylor Swift and Selena Gomez: After dating members of the Jonas Brothers simultaneously, the singers created their own squad. Despite rumors and lack of Instagram evidence, they remain closer than ever. Gomez even made an appearance at one of Swift’s Reputation shows in 2018.

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15. Matt Damon and Ben Affleck: This friendship goes way, way back. Damon and Affleck met while in elementary school in their hometown of Cambridge, Massachusetts. As both of their careers were picking up traction, the pair co-wrote Good Will Hunting in 1997.

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16. Natalie Portman and Rashida Jones: Even though both call Harvard their alma mater, these two didn’t become close until their Hollywood days. Up until recently, Jones was Portman’s only famous friend. Portman shared, “She would fight beasts 10 times her size to protect the people she loves.”

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17. Jon Hamm and Paul Rudd: Things weren’t always so chummy between the actors. In fact, they crossed paths while in pursuit of the same woman when Rudd was a freshman in college and Hamm was a junior in high school. Neither of them got the girl, but they ended up with each other instead.

18. Jennifer Aniston and Ellen DeGeneres: Sure, Aniston frequents DeGeneres’ show to promote her upcoming work, but she also just stops by the studio to see her dear friend. They often enjoy casual dinners together and never miss each other’s birthday party.

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19. Reese Witherspoon and Kate Winslet: These two became friends when Winslet moved into Witherspoon’s neighborhood. Apparently, Winslet knocked on Witherspoon’s door and introduced herself. That’s one way to start a friendship!

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20. Emma Stone and Jennifer Lawrence: Introduced by Woody Harrelson, the actresses have formed a strong bond over their awkward, yet endearing, personas. On several occasions, they’ve requested that their bestie be the interviewer for Q&As with big names like W Magazine and Elle.

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21. Cara Delevingne and Kendall Jenner: Both models, Delevingne and Jenner met while working the same fashion show back in 2014. They still remain close friends even though work keeps them on opposite ends of the world.

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For every friendship, Hollywood creates a feud, too. Richard Gere was chowing down on a particularly greasy chicken inside Sylvester Stallone’s car and ended up dropping grease on his pants. Things haven’t been the same since.

2. Kim Cattrall and Sarah Jessica Parker: While the women played best friends on screen, in real life Cattrall has spoken out about mean girl culture surrounding Sex In The City and has referred to costar SJP as “cruel” and “toxic”.

3. Bette Davis and Joan Crawford: These two iconic Hollywood actresses had real beef with one another. On the set of one movie, Davis ensured that a Coke machine be placed in the latter’s dressing room — Crawford’s husband worked for Pepsi.

4. Bruce Willis and Kevin Smith: Willis starred in Smith’s 2010 movie Cop Out and the latter had some highly negative things to say. Apparently Willis was disagreeable enough that Smith described the experience as “soul-crushing.”

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5. Claire Danes and Leonardo DiCaprio: While these two played iconic lovers in Romeo and Juliet, in reality, their personalities just clashed. Danes thought DiCaprio was obnoxious with his constant pranks; DiCaprio found Danes uptight and reserved.

6. Bill Murray and Lucy Liu: Murray seems like a nice enough guy, but during the filming of one scene in Charlie’s Angels he stopped everything to tell Liu she couldn’t act and questioned why she was there. Liu responded by punching him.

7. Katherine Heigl and Judd Apatow: After starring in Apatow’s comedy Knocked Up, Heigl had some negative things to say about the film in the press, including calling it sexist. Apatow was offended by the comments, and claims never to have received an apology.

8. LL Cool J and Jamie Foxx: When playing rivals in Any Given Sunday, things got a little too heated between these two, and LL Cool J knocked Jamie Foxx out. Apparently the police even had to get involved. Not great.

9. Kiefer Sutherland and Freddie Prinze Jr: Prinze notably took issue with Sutherland’s heavy drinking and debaucherous antics on set, and even called him “the most unprofessional dude in the world.” Needless to say they won’t be acting together again.

10. Tom Hardy and Charlize Theron: While starring in Mad Max: Fury Road together, these two stars found themselves constantly feuding. To be fair, however, Theron herself says part of the animosity can be attributed to the harsh conditions of the desert set.

11. Shia LaBeouf and Alec Baldwin: Once upon a time these two leading men were slated to costar in a play, but tensions arose when LaBeouf got arrogant about having memorized all his lines before rehearsal. He told Baldwin he was “slowing him down.”

12. Sharon Stone and William Baldwin: Another Baldwin brother! These onscreen lovers actually didn’t get a long at all. Things came to a head when during a romantic scene Stone bit Baldwin’s tongue so hard he couldn’t speak for a week.

13. Nina Dobrev and Ian Somerhalder: While the two began to date after playing vampire lovers in The Vampire Diaries, once they broke up, they initially couldn’t stand to be in the same room together, which must have made reunion parties awkward.

14. James Franco and Tyrese Gibson: Apparently Franco took his penchant for method acting a little too far for Gibson while filming Annapolis. The latter reported that Franco was incredibly hostile the whole time. He even worried that Franco wanted to “blow up [his] hotel room”.

15. Terri Hatcher and the Desperate Housewives cast: The women were thick as thieves on TV, but in reality Hatcher was increasingly isolated from her costars. One actress even called her “the meanest woman in the world.” Ouch.

Desperate Housewives

16. Tina Fey and Paris Hilton: When Hilton was a guest host on Fey’s SNL, the two quickly butted heads. Fey later had disparaging things to say about the heiress, insulting her “nasty Barbie hair” and self absorption.

17. David Russell and George Clooney: While filming the Russell-directed Three Kings, scheduling conflicts along with pay cuts created friction between the two celebs. The mutual dislike culminated in a physical tussle that both fortunately left relatively unharmed.

18. Nicki Minaj and Mariah Carey: These two are often classified as divas in their own right, so when the two got together to work as judges on American Idol the wrong kind of sparks definitely flew. Nicki even said if she had a gun she’d shoot Mariah.

19. Kathy Griffin and Anderson Cooper: These two used to be BFFs, but after Griffin came under fire for sharing a controversial image, Cooper began to distance himself from the comedian. For her part, Griffin says the friendship is irreconcilable.

20. Charlie Sheen and Selma Blair: After Sheen reportedly attempted to get Blair fired from Anger Management, the actress was not pleased. The two have not spoken or appeared on set together since.